Instruct/CIISB course on fragment screening using crystallography laboratory equipment

Accommodation for the participants to the practical (hands-on) sessions: shared rooms (2 people), Hotel u Krbu, Vídeňská 360, 252 42 Vestec, Czech Republic

Aims of the course:

Fragment-screening (FS) is a popular approach to identify the binding of small organic molecules (fragments) to protein targets. This may be done to elucidate the function of a protein or to identify target-binding chemical structures, which then may be developed into inhibitors in a process called lead compound discovery.


Expected impact for (young) researchers:

The workshop will allow participants for the hands-on sessions (16), with some prior knowledge and experience in practical macromolecular crystallography, to access the biophysical measurements (microscale thermophoresis and/or surface plasmon resonance) and X-ray diffraction sections of the Instruct CZ / CIISB CMS location. The workshop will allow them to acquire knowledge and practical experience on how to apply fragment-screening techniques to a real case. Depending on the proposals made by the participants, one or two of the participants’ project may be selected to be used for demonstrations (one sample suitable for biophysical measurements; a sufficient number of one type of macromolecular crystals – both brought by the selected participants, to be arranged in advance).

Opportunity for participants to bring their own samples: Yes (see above), must be arranged in advance

Contact: F. Vellieux ( To apply, send a letter by email indicating how you would benefit from attendance. In case of junior scientists, a letter of confirmation from your supervisor is also requested. Please also indicate if you would like to bring a poster.

Registration fee: none – the registered participants (16) are expected to cover the costs of travel to and from Vestec (arrival in Vestec on April 4 evening, departure from Vestec on April 7 morning). The registration for the 16 selected participants (for the practical sessions) covers all costs from the first night in Hotel u Krbu to the final night (departure after breakfast on April 7). Note that accommodation plus catering costs will be charged in case of “no show”.